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In contrast, the presence of albumin was associated with an enrichment of particularly lipids and some specific amino acid metabolites extracellularly (cluster 3

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In autoimmune hepatitis and T-cell-mediated hepatitis models, gut microbiota-derived ICA induces the expression of PI3K-interacting protein 1 by activating AhR in CD8 + T cells, thereby inhibiting the PI3K/Akt/mTOR pathway, limiting excessive activation of effector T cells, and attenuating liver injury

In the 27 patients with at least a 15% reduction in LDL-C, the mean LDL-C reduction was 30% (median 28% reduction)