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Astrocytic low-density lipoprotein receptor-related protein 1 (LRP1) can promote astrocyte-to-neuron mitochondria transfer by inhibiting glycolysis and ARF1-K73la, thereby mitigating cerebral ischemia

In addition, it appears to modulate various molecular pathways that are involved in inflammation, immune function, and nerve regeneration

ZIP synergy scores less than -10 were considered antagonistic, scores from -10 to 10 were considered additive and scores greater than 10 were considered strong synergistic (PMID: 35580060)

The cold is constant, but there is more sun in the summer

P-glycoprotein (P-gp) plays a role in ACs efflux transport, though some studies report low permeability without significant efflux activity (Gao et al