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2024 Mar 8

The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system

reported that anoctamin 1 (ANO1) interacts with JUN to suppress CYP27A1-LXR signaling, leading to intracellular cholesterol accumulation and TME reprogramming, thus enhancing esophageal squamous cell carcinoma metastasis [79]