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Values are approximate and may vary depending on route of administration, formulation, species, and assay methodology

Many individuals may experience deficiencies due to dietary restrictions, absorption issues, or increased physiological demands

(6.1) The most common adverse reactions (incidence 20%) of pemetrexed when administered in combination with pembrolizumab and platinum chemotherapy are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia