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The oxidation of monoamines in neurotransmitters such as serotonin by MAO-A results in the intracellular accumulation of reactive oxygen species (ROS) ( Figure 1A ) ( Potential Of MAOIs As ICB Therapy MAO-A regulation of T cell activity was further investigated through the administration of MAOIs as a means of artificially inhibiting MAO-A activity and the breakdown of serotonin