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Oxidative modifications may impair the expression or activity of sarcoplasmic reticulum Ca 2 -ATPase (SERCA2a), leading to defective Ca 2 reuptake during diastole, sustained cytosolic Ca 2 elevation further causes diastolic dysfunction and delayed relaxation [44]

Miller Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy Giuseppe Minervini Saveetha Dental College and Hospitals, Saveetha University, Chennai, India Giuseppe Minervini & Marcos Roberto Tovani-Palone Department of Public Health Dentistry, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India GK Mini Global Institute of Public Health, Ananthapuri Hospitals and Research Institute, Trivandrum, India GK Mini Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran Mojgan Mirghafourvand Internal Medicine Programme, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan Erkin M