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8 This was the first trial in patients with a first acute demyelinating event (now, clinically isolated syndrome) to show efficacy in delaying time-to-clinically definite MS and was recognized as a significant medical advance as it introduced the concept of early treatment and led to revisions in diagnostic criteria for MS

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Macrophages are phenotypically plastic phagocytic cells widely distributed throughout the body and can adopt a variety of polarisation states depending on their environment 15