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Our team strongly advises against it

Anyone with active or prior malignancy, uncontrolled or impaired glucose tolerance/diabetes without oversight, pregnancy or breastfeeding, or pituitary/hypothalamic disease

It attaches partially to beta-3 adrenergiclinked pathways in fat tissue, which activates lipolysis and fat breakdown without influencing appetite, blood glucose or CNS signals

Many weight loss methods, including GLP-1 medications like semaglutide and retatrutide , lead to unintended loss of lean mass