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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al

Our previous data from 8 weeks versus data from 4 weeks showed that consumption of LFME3 enriched kefir, but not the placebo kefir, significantly decreased the level of LDL cholesterol [34]

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Gpx4 is a crucial intracellular lipid peroxidation-detoxifying enzyme (Yant et al., 2003), and its inactivation not only participates in ferroptosis but also remains the main mechanism supporting this process (Krantz et al., 2005