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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

In summary, the autophagy-ferroptosis axis exhibits dual roles in LC biology

Lipophilic radical-trapping antioxidants such as -tocopherol (vitamin E) can interrupt this chain reaction by donating hydrogen atoms to lipid peroxyl radicals, thereby preventing cells from undergoing ferroptosis [69]

Advanced analytical techniques are enabling researchers to track the compound's effects on global metabolite profiles, revealing complex interactions between NAD+ metabolism, methylation cycles, and other metabolic pathways that were previously unappreciated