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TLR9endosomal sensing of CpG DNA TLR9 is a specialized PRR that evolved to detect unmethylated CpG motifs, which are abundant in bacterial DNA and mtDNA but relatively rare and typically methylated in nuclear DNA [123, 124]

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This can occur without a change in the number of receptors or the ability of a receptor to affect the downstream signaling molecules

Without adequate B12, cells cannot replicate their DNA accurately rapidly dividing cells (including follicle matrix cells) are among the first affected

This property helps in reducing microbial load and subsequent inflammation