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It indicated patients with PNP may gain benefit from ALC administration

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Cuando clulas son expuestas a citocinas inflamatorias, a especies reactivas de oxgeno, a lipopolisacrido bacteriano, o a otros estmulos, quinasas de IkappaB fosforilan protenas IkappaB marcndolas para degradacin proteasomal, liberando NF-kappaB que transloca a ncleo donde se une a secuencias kappa B en promotores de genes diana activando transcripcin

Interestingly, pseudo-obstruction is also caused by mutations in the nuclear POLG and TMEM70 genes