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As an NADPH-selective enzyme, FSP1 suppresses ferroptosis by oxidizing NADPH

Moreover, liproxstatin-1 (Lip-1) and peroxisome proliferator-activated receptor activator troglitazone have exhibited promising potential in preventing hepatic IRI by restraining ferroptosis (Friedmann Angeli et al., 2014

Short N, Jabbour EJ, Ravandi F, Huang X, Jain N, Sasaki K, Pemmaraju N, Daver NG, Khoury JD, Jorgensen JL, Alvarado Y, Konopleva MY, Garcia-Manero G, Kadia TM, Yilmaz M, Borthakur G , Burger JA, Kornblau SM, Wierda WG, DiNardo CD, Ferrajoli A, Nasnas P, Jacob J, Garris RE, OBrien SM, Kantarjian H

In the normal state when gluatione stores are adequate gluathione exerts a negative feedback inhibition on the enzyme -glutamyl cysteine synthase which regulates the cycle