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Samam Prez-Vargas et al., 2013

Characterization of EDP-305, a highly potent and selective farnesoid X receptor agonist, for the treatment of non-alcoholic steatohepatitis

These kind of study although have some limitations

For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)

Methods: Participants with first lacunar or mild cortical ischaemic stroke underwent brain magnetic resonance imaging (MRI) at diagnosis, then brain MRI and macular optical coherence tomography angiography (OCTA) at baseline, 3-, 6-, and 12-months