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DOto, A

Chinese Journal of Pharmacology: English Edition , 2002, 23(5): 412-422 4

A single process underlying different hyperglycemia-induced pathogenic mechanisms: mitochondrial superoxide production Specific inhibitors of aldose-reductase activity, AGE formation, RAGE ligand binding, PKC activation and hexosamine pathway flux each ameliorate various diabetes-induced abnormalities in cell culture or animal models, but it has not been clear whether these processes are interconnected or might have a common cause [99,131134]