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In parallel, the alcohol-mediated zinc deficiency inhibits activation of the anti-oxidant response element by decreasing signaling through its master transcription factor, Nrf2

Total protein levels of Bcl-2 were significantly decreased (77.6 6.1%) but the total protein levels of Bax and cleaved caspase-3 were significantly increased (598.2 69% and 291.4 23.5%, respectively) in the livers of APAP-treated rats as compared to control rats ( Fig