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Thus, although changes in lipid composition can have a significant impact in membrane physical properties, which in turn affect mitochondrial function, the cumulative evidence points to a crucial role for cholesterol accumulation in orchestrating these deleterious effects in mitochondria via impaired antioxidant defense and subsequent ROS generation, affecting essential unique lipid components like CL

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The ensuing hepatic enlargement and tissue injury may progress to cirrhosis or malignancy [2]

Basic Science of the Innate Immune System and the Lung

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