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WangDDMaoYZYangYWangTYZhuPHeSMet alEffects of sodium-glucose cotransporter-2 inhibitors on weight in type 2 diabetes mellitus and therapeutic regimen recommendation

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3.1.4.3 Strategies to bridge translational difficulties To improve clinical translatability, the following strategies are recommended: (1) Multi-species validation: mechanisms discovered in mice should be validated in rats, rabbits, or non-human primates