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Treatment was also associated with reductions in body weight, high-sensitivity C-reactive protein level, systolic blood pressure and improvements in sleep-associated patient-reported outcomes

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April 15, 2026 update: The FDA's revised 503A document removes TB-500 (both TB-500 acetate and TB-500 free base) from Category 2 and schedules it for PCAC review on July 23, 2026

The study further identified many antimalarial drugs which have shown antimalarial activities against a strain moderately resistant to chloroquine [87]

Additionally, a 2020 mm specimen was extracted from the non-damaged tissue of the upper back for the purpose of weight determination at days 1, 2, and 3 following euthanization