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1 Introduction In the mid-19th century, Rudolf Virchows cellular theory concluded that all diseases, including cancer are a result of alterations in cells, resulting in an understanding of cancer as a disease of abnormal cell proliferation ( One of the major hurdles in the treatment of cancer is chemoresistance that is similar to the resistance to drugs in infectious disease ( The cancer heterogeneity is considered as a main factor in cancer drug resistance that is a result of genetic alterations caused by mutational processes ( 2 Autophagy fundamentals and molecular machinery 2.1 Autophagy basics and molecular machinery Autophagosome biogenesis is considered as a dynamic molecular process and it is a particular aspect of research ( LC3 was initially identified in the rat brain as a light chain of microtubule-associated proteins 1A and 1B, including two isoforms, LC3A and LC3B