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doi: 10.1016/j.phrs.2017.09.010 227 DehzadMJGhalandariHNouriMAskarpourM

As novel hyaluronic acid derivatives, SAGE exhibits broad anti-inflammatory effects by effectively binding to and inhibiting RAGE (receptor for AGEs) to reduce the inflammatory response

(1993), Tuaillon et al

This finding has led to better understanding of the regulatory mechanism for ROS signals and speculation that DM, DR and retinal cell degeneration are closely associated with ROS-induced hyperglycemia and oxidative stress 8,12,13,14