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While DIA typically yields increased peptide identifications compared to DDA, it often produces a lower proportion of confidently localised sites due to the increased spectral complexity, a challenge that is further exacerbated in low-input workflows, where the intensity of diagnostic fragment ions is reduced (Muneer et al., 2024, Kitata et al., 2021)

Yamanaka K, Komine O

Category 2 of the FDA's 503A list is reserved for bulk drug substances that "raise significant safety concerns." Placement in this category essentially prohibits compounding pharmacies from using the substance to prepare formulations for patients

To account for differences in soil composition, metal concentrations were also normalized to Fe, which improved statistical resolution and clarified site-level distinctions, particularly for Cu