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Of note, cells lacking LRP6 alone (LRP6 KO) cannot respond to Wnt (except for the Wnt-induced destabilization of Axin), whereas LRP5 KO cells are as Wnt responsive as their parental controls (Supplementary Fig

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In this study, we conducted MR analysis utilizing the TwoSampleMR software package (version 0.6.8) within the R programming environment.We selected two large plasma pQTLs as exposure data and MS as outcome data

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Collectively, these findings reveal that IRE1 negatively regulates cellular GSH availability and maintains cellular sensitivity to ferroptosis by dampening GCLC expression through its RIDD activity