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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

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We assume that the function, S ( t ), which multiplies the V max values of GCL and GPX, is a linear function of E 2( t ) as follows: Figure 2

In melanocytes, CAT primarily manages HO degradation, providing a critical defense against oxidative stress 57