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These pathways are biologically plausible

Eicosanoid storm in infection and inflammation

& Guo, B

All protein and ligand atoms were treated as anisotropic in B -factor refinement if the structure was at least 1.4 in resolution, as for the papainE-64d and papain(2 S ,3 S )- t -ES- a9 - b7 structures, although solvent atoms remained isotropic

Since alterations in cellular metabolic status can induce autophagy through activation of the energy sensor AMPK and inhibition of mTORC1 pathway 11,12 , we investigated the activity of both in non-lesional vitiligo melanocytes