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The results showed that ERK, JNK and P38 were all activated after MIRI (Figures 7A, B), among them, Sat1 inhibition only significantly suppressed the activation of MAPK/ERK, but Sat1 over-expression did not significantly promote the activation of MAPK/ERK (Figure 7B)

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10.1021/bi00559a004 40 ShanerN.SteinbachP.TsienR

Researchers monitoring GI adverse events should collect data on meal patterns to differentiate compound-related GI effects from dietary confounders, particularly during the first 812 weeks of dose escalation when GI adverse events are most frequent