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In the tryptophan metabolism, the two species are both lack of the degradation pathway

11 By comparison, GSTP1 can arrest tumor cells in the G0/G1 phase and upregulate the expression of p21 in bladder cancer

They found in the mouse study that they needed 15 days either by giving a long-acting formulation or just giving it for 15 days in a mouse, which has faster metabolism than we do