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Description

This accumulation promotes Parkin recruitment and activates its E3 ubiquitin ligase activity, resulting in the ubiquitination of damaged mitochondria and the initiation of autophagic degradation

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The Endoplasmic reticulum stress response in prostate cancer

Ataxin-3 binds to both native and polyubiquitinated TP53, and deubiquitinates and stabilizes it by blocking its degradation via the ubiquitinproteasome pathway 103