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This prevents neuronal ferroptosis induced by oxidative stress, alleviates glia overactivation, inhibits the secretion of pro-inflammatory factors, and regulates the inflammatory microenvironment

Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]

In addition, the acceptance of coffee enemas among patients also needs to be studied

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They even suggest a mechanism involving cytokine dysregulation (Lomeli et al