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doi: 10.1021/acs.molpharmaceut.1c00018 [DOI] [PMC free article] [PubMed] [Google Scholar] 413

In particular, the daily lightdark cycle represents the primary external synchronizer of circadian rhythms

The therapeutic effect of NOS recoupling on endothelial dysfunction in hypertension, diabetes, and myocardial infarction is well recognized ( in vivo tumor models and patient biopsies ( in vivo ( NOS uncoupling and BH4 depletion Biopterins are reductive, enzymatic cofactors required by organisms in all kingdoms of life ( NOS uncoupling is also accompanied by a consequential shift in NO-mediated signaling, which is relevant both to tumor progression as well as the anti-tumor immune response

Elevation of the inflammatory response can include a pain response

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