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The enzymes responsible for this digestion (pepsin in the stomach, trypsin and chymotrypsin from the pancreas in the small intestine) are highly efficient and rapidly degrade most therapeutic peptides to pharmacologically inactive fragments before they can act on mucosal tissue

Weight regain is possible if caloric intake increases significantly or exercise decreases

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The arginate form also offers advantages for systemic applications where the researcher wants broad distribution rather than localized effects

Conditions like Crohns disease or celiac disease can hinder absorption of nutrients, including B12