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The application of broad spectrum Gln metabolic antagonists can mitigate drug resistance in NSCLC and improve the clinical efficacy of osimertinib (29)

Its structure features an N-terminal domain and a C-terminal domain, with the active site located between them

3 Institute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany