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Alpha-1 and alpha-2 receptor stimulation causes peripheral vasoconstriction, increases blood pressure, and reduces mucosal and vascular edema

Finally, epigenetic regulatory networks are incompletely characterized: while individual ubiquitinases, miRNAs, or demethylases are implicated, the integrated epigenetic landscape governing ferroptosis in I/R AKI (e.g., crosstalk between ubiquitination and miRNA-mediated silencing, or epigenetic memory of ferroptosis susceptibility) remains unclear

Gastroenterology 158 , 18511864

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In contrast, in a hypertensive nephropathy model, USP25 inhibited the TGF- signaling pathway by suppressing the ubiquitination process of Smad4, delaying renal fibrosis and protecting renal function[106]