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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

10.1186/s13148-014-0035-3 54 GuoX

Myers B, Mark Dolgas C, Kasckow J, Cullinan WE, Herman JP

Whereas most of these reversible modifications lead to protein inactivation, S-sulfhydration can be distinct since it usually activates the targeted proteins as shown for GAPDH and p65 ( All these observations suggest that there may be biological differences for each of these different PTMs and possibly hierarchies

While there was no control group included, the placebo response in such refractory patients is notoriously low, and this response rate therefore is quite encouraging