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In: Litwack G (ed) Human biochemistry

Skeletal muscle protein balance regulation Skeletal muscle mass depends on the rates of protein synthesis and degradation

Given that inhibition of IGF-IR may paradoxically lead to upregulation of IGF1/2 expression, and IGF1/2 have IGF-IR/InsR-independent functions, it warrants to investigate whether co-targeting IGF and IGF-IR/InsR-A may achieve objective responses

Role of 4-hydroxynonenal and its metabolites in signaling

Remarkably, GSH depletion significantly decreased the expression of these key fibrogenic factors under both chow and HFD conditions (Figure 3, A and B)