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doi: 10.1016/j.bbalip.2013.10.008 6 AmbroggioE

In comparison, in an Ecuadorian kindred with GH receptor deficiency and very low levels of IGF-I, rates of cancer and diabetes were markedly reduced compared to unaffected people in the same communities (39)

These are similar to those seen in younger adults with growth hormone deficiency

The following sections examine how these core mechanisms translate into condition-specific effects across major cardiovascular pathologies, highlighting how metformins multifaceted actions may offer therapeutic value across diverse cardiac settings