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This adaptation renders them addicted to GPX4, as its continuous activity is required to suppress lipid peroxidation triggered by oncogene-induced oxidative stress (Figure 3) (Lim and Leprivier, 2019)

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Notably, four metabolic pathways include Metabolism of xenobiotics by cytochrome P450, Isoquinoline alkaloid biosynthesis, AGERAGE signaling pathway in diabetic complications, and Meiosis yeast were identified as overlapping across the pairwise comparisons, suggesting their potential key roles in the therapeutic regulation of UC by TLYY

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