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GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

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In addition, since cell death processes may intricately regulate each other, the straightforward inhibition of a particular cell death modality may not present the optimal therapeutic solution against the complexity of diseases pathophysiology

The glutathione peroxidase gene family in Thellungiella salsuginea : genome-wide identification, classification, and gene and protein expression analysis under stress conditions