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During the pivotal inflammatory cascade activation phase, a sophisticated arsenal of anthraquinone constituents, exemplified by rhein and physcion, implements strategic suppression of NF-B and STAT3 signaling networks, while hirudin provides targeted inhibition of NLRP3 inflammasome activation, and triterpenoid compounds orchestrate comprehensive modulation of TLR4/MyD88 cascades, collectively establishing a coordinated attenuation of pro-inflammatory mediator expression throughout the entire gut-kidney axis continuum

The standard 250-500 mcg per day remains appropriate

Breschi L, Cadenaro M, Antoniolli F, Visintini E, Toledano M, Di Lenarda R

LiaoYXieBZhangHHeQGuoLSubramanieapillaiMet al

10.1002/14651858.CD001287.pub6 Cochrane Database Syst Rev