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It incorporates four major changes compared with the 2002 system

Melanotan-2 stimulates MC1R receptors to produce melanin without UV exposure, theoretically bypassing those protective mechanisms

These include a limited ability to repair damaged elements due to the loss of protein expression during erythropoietic maturation, high levels of molecular O 2 bound to Hb, which results in an abundance of oxidants, and high levels of iron within the prosthetic group of Hb, which can cause ROS production via the Fenton reaction

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The move would reverse a decision made in 2023 by the Biden administration, which barred certain peptides from being compounded