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Succinate is the product of 2-OGDD enzymes reactions and thus its accumulation inhibits these enzymes

Cross-talk between TRX and the GSH/GRX system has been evidenced in Arabidopsis thaliana mutants lacking the cytosolic GR1 or GR2 in mitochondria, where the TRX system can serve as a back-up system for local control of GSSG accumulation in the respective compartment [28, 29]

Furthermore, the myelin sheath helps conserve energy by reducing the number of ions that need to be pumped back out of the axons to bring them back to the resting potential and allow for more action potentials (Arancibia-Carcamo et al

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