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The lack of B12 halts the methylation cycle, which leads to a buildup of toxic homocysteine

Furthermore, among apoptosis-related genes, Atf3, Ddit3, and Txnip are involved in oxidative and ER stress 40,41,42

Lacosamide is a safe and well-tolerated agent which has been demonstrated to be effective in managing pain due to DPN either as a monotherapy [44, 45]) or as an add-on [46]