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Additionally, the accumulation of reduced GSH can inhibit the effect of cisplatin and cyclophosphamide through the formation of less toxic glutathione S-conjugates 41,57

In addition, it has also been reported that CLOCK is available to bind to other target proteins such as the p65 subunit of NF-kB (40) which in the lens has been shown to be associated with oxidative-induced damage in human lens epithelial cells (41)

It is known that both T1DM and T2DM are characterized by increased ROS production, which correlates strongly with the development of diabetes and its associated complications [110, 111]

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA (2019) Ischaemic stroke