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M., Heras, S

May 25 2021;doi:10.1007/s42000-021-00289-z Gadalla MA, Norman RJ, Tay CT, et al

It has also been demonstrated to impair the uptake of essential amino acids by the transporter protein SLC38A2, thereby decreasing the cellular levels of these nutrients [175]

418,419 ATM First identified in 1995, the ATM kinase contains a PI3K-like kinase domain at the C-terminal and represents the core regulator for DNA double-strand break and repair

During ageing, mtDNA, Tfam, ROS, ATP, cardiolipin, and N-formyl peptide can be released as DAMPs and are recognized by pattern recognition receptors upon mitochondrial stress or compromise, leading to the activation of MiDAS and SASP