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human clinical trials are ongoing as of 2026

Additionally, SARS-CoV-2 has been shown to infect and replicate within the oral epithelium, with oral dysbiosis potentially associated with enhanced viral entry through upregulation of ACE2 expression mediated by bacterial enzymes that mimic furin activity [118]

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Advances in drug delivery systems, including liposomes and nanophytosomes, address low solubility, rapid metabolism, and limited blood brain barrier penetration, thereby improving central nervous system exposure and pharmacodynamic effects, which is essential for clinical translation of several phytochemicals (Moghaddam et al., 2023

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