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The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis

Moreover, elevated levels of leptin, a prevalent occurrence in individuals with obesity, have been shown to stimulate the secretion of vascular endothelial growth factor (VEGF) by airway ASM cells (293), suggesting that leptin may indirectly contribute to the obesity-induced bronchial vascular remodeling processes in individuals with asthma and obesity

Exploration of uncharted regions of the protein universe

Compared with other flavonoids, Lut has a stronger research basis for its anti-asthmatic properties and has been shown to relieve a range of asthma symptoms, including airway inflammation [18], airway hyperresponsiveness, bronchoconstriction [19], airway mucus hypersecretion [20], and lung autophagy [21], as well as neutrophil asthma in OVA/LPS-stimulated asthmatic mice [22]

Diabetes affects the activity of many metabolic pathways (AGEs, PKC, polyol pathway, PP), and one consequence of activating these metabolic pathways is the generation of ROS (Kowluru, 2023)