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Ajibade TO, Oyagbemi AA, Omobowale TO et al (2017) Quercetin and Vitamin C mitigate cobalt chloride-induced hypertension through reduction in oxidative stress and nuclear factor kappa beta (NF-Kb) expression in experimental rat model

Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

Overall, investigations have revealed that engaging in exercise can diminish leptin levels in those with atherosclerosis, thereby reducing the pathological development of atherosclerosis

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