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doi: 10.1111/ics.13079 26

Valko M, Jomova K, Rhodes CJ (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

Diagnosis includes a skilled clinical assessment, evaluating symptoms already discussed (e.g

WASP and SCAR homologs (WASH)

Sustained mPTP opening collapses the mitochondrial membrane potential (m), uncouples oxidative phosphorylation, and causes osmotic swelling, outer membrane rupture, and the release of pro-apoptotic factors such as cytochrome c, thereby initiating caspase-dependent apoptosis