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Targeting early degenerative changes, such as synaptic loss, axonal transport disruption, mitochondrial compromise, and glial dysfunction, may prove more effective than attempting to reverse advanced neuronal death [27, 28]

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Salvianolic acid A (PubChem CID: 5281793) has been identified as a particularly effective agent that possesses anti-inflammatory and antioxidant properties, as well as the ability to modulate the integrity and functionality of the BBB ( 2+ production and reversed the downregulation of GSH, XCT, and GPX4 ( Carvacrol (PubChem CID: 10364) is a natural compound that occurs in the leaves of several plants and botanical drug including wild bergamot, thyme and pepperwort, but which is most abundant in Origanum vulgare L

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Essentially, the bodys ability to produce and recycle reduced glutathione determines how effectively it can defend against oxidative stress and maintain cellular health over time

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ECs from the vascular endothelium (from both the macro and microcirculation) produce ATP mainly by glycolysis [32]

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