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Dihexa significantly decreased levels of pro-inflammatory cytokines including interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), both implicated in synaptic dysfunction and neuronal death in Alzheimer's disease

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Lau and Sarkar found also that GHK can easily obtain copper 2+ bound to other molecules such as the high affinity copper transport site on plasma albumin (albumin binding constant log 10 = 16.2 versus GHK binding constant 16 log 10 = 16.44)

Yap et al., 2016)

TIMP-1 and TIMP-2 tissue inhibitors of metalloproteinases are upregulated, further tipping the balance toward matrix preservation